Publications

Here is a list of publications and Pubmed links (updated May 2015). Please contact Harley Kurata with requests or inquiries.
2015
  • Kim, R.Y., Yau, M.C., Galpin, J.D., Seebohm, G., Ahern, C.A., Pless, S.A., and H.T. Kurata. Atomic basis for therapeutic activation of neuronal potassium channels. Nat Communabstract
  • Zhang, R.S., Wright, J.D., Pless, S.A., Nunez, J.J., Kim, R.Y., Li, J.B., Yang, R., Ahern, C.A., and H.T. Kurata. A Conserved Residue Cluster That Governs Kinetics of ATP-dependent Gating of Kir6.2 Potassium Channels. J Biol Chem. abstract
  • Baronas, V.A., McGuinness, B., Vilin, Y.Y., Kim, R.Y., Wang, L., Lynn, F.C., Bamji, S.X., Yang, R.Y. and H.T. Kurata. 2015. Use-dependent activation of neuronal Kv1.2 channel complexes. J. Neurosci. abstract
  • Pless, S.A., Kim, R.Y., Ahern, C.A., and H.T. Kurata. 2015. Atom-by-atom engineering of voltage-gated ion channels: magnified insights into function and pharmacology. J. Physiol. abstract
  • Harel, S., Cohen, A., Hussain, K., Flanagan, S., Schlade-Bartusiak, K., Li, J.B.W., Van Karnebeek, C., Kurata, H., Ellard, S., Chanoine, J.P. and W.T. Gibson. 2015. Alternate hypoglycemia and hyperglycemia in a toddler with a homozygous p.R1419H mutation of ABCC8: An unusual clinical picture. J Pediatr Endocrinol Metab. abstract
2014
  • Baronas, V.A., H.T. Kurata. 2014. Inward rectifiers and their regulation by endogenous polyamines. Frontiers in Physiology abstract
  • Pless, S.A., Elstone, F.A., Niciforovic, A.P., Galpin, J.D., Kurata, H.T., and C.A. Ahern. 2014. Functional contribution of acidic and aromatic side chains in sodium channel voltage-sensor domains. J. Gen. Physiol. abstract
  • Yang, Y.H.C., Vilin, Y.Y., Roberge, M., Kurata, H.T., and J.D. Johnson. 2014. Multi-parameter screening reveals a role for Na+ channels in cytokine-induced beta-cell death. Molecular Endocrinology. abstract
  • Bruin, J.E., Erener, S., Vela, J., Johnson, J.D., Hu, X., Kurata, H.T., Lynn, F.C., Piret, J.M, Rezania, A.and T.J. Kieffer. 2013. Modeling human fetal pancreas development in vitro using human embryonic stem cells. Stem Cell Research. abstract
2013
  • Pless, S.A., Galpin, J.D., Niciforovic, A.P, Kurata, H.T., and C.A. Ahern. 2013. Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels. ELife. abstract
  • Li, B.W., Huang, X., Zhang, R., Kim, R.Y., Yang, R., and H.T. Kurata. 2013. Decomposition of slide helix contributions to ATP-dependent inhibition of Kir6.2 channels. J. Biol. Chem. abstract
  • Vilin, Y.Y., Nunez, J.J., Kim, R.Y., and H.T. Kurata. 2013. Paradoxical activation of a Kir channel mutant by spermine: ‘(b)locking’ open the bundle crossing gate. Mol. Pharmacology. abstract
  • Pless, S.A., Niciforovic, A.P., Galpin, J.D., Nunez, J.J., Kurata, H.T., and C.A. Ahern. 2013. A novel mechanism for regulating open state stability in a voltage-gated potassium channel. Nature Communications. abstract
  • Kurata, H.T., Akrouh, A., Li, J.B.W., Marton, L.J., and C.G. Nichols. 2013. Scanning the topography of polyamine blocker binding in an inwardly-rectifying potassium channel. J. Biol. Chem. abstract
  • Sala-Rabanal, M., Li, D.C., Dake, G.R., Kurata, H.T., Inyushin, M., Skatchkov, S.N., and C.G. Nichols. 2013. Polyamine Transport by the Polyspecific Organic Cation Transporters OCT1, OCT2, and OCT3. Mol. Pharm. abstract

2012

  • Ponce-Balbuena, D., Rodríguez-Menchaca, A.A., López-Izquierdo, A., Ferrer, T., Kurata, H.T., Nichols, C.G., and J.A. Sánchez-Chapula. 2012. Molecular mechanisms of the cardiac IKATP (Kir6.2/SUR2A) channel inhibition by the antimalarial drug chloroquine. Mol. Pharmacology. abstract

2011

  • Khurana, A., Shao, E.S., Kim, R.Y., Vilin, Y.Y., Huang, X.,Yang., R.Y., and H.T. Kurata. 2011. Forced gating motions by a substituted titratable side chain in the bundle crossing of a potassium channel. J. Biol. Chem. abstract
  • Kurata, H.T., Cheng, W.W., and C.G. Nichols. 2011. Polyamine block of inwardly-rectifying potassium channels. Methods. Mol. Biol. abstract
  • Zhang, H.X., Akrouh, A., Kurata, H.T., Remedi, M.S., Lawton, J.S., and C.G. Nichols. 2011. HMR 1098 is not an isotype specific inhibitor of heterologous or sarcolemmal K(ATP) channels. J. Mol. Cell. Cardiol. abstract
  • Loechner, K.J., Akrouh, A., Kurata, H.T., Dionisi-Vici, C., Maiorana, A., Pizzoferro, M., Rufini, V., deVille de Govet, J., Colombo, C., Barbetti, F., Koster, J.C., and C.G. Nichols. 2011. Congenital hyperinsulinism and glucose hypersensitivity in homozygous and heterozygous carriers of Kir6.2 (KCNJ11) mutation V290M mutation: KATP channel inactivation mechanism and clinical management. Diabetes. abstract

2010

  • Kurata, H.T., Rapedius, M., Kleinman, M.J., Baukrowitz, T., and C.G. Nichols. 2010. Voltage-dependent gating in a voltage sensor-less ion channel. PLoS Biology.
    abstract
  •  Kurata, H.T., Zhu, E.A., and C.G. Nichols. 2010. Locale and chemistry of spermine binding in the archetypal inward rectifier Kir2.1. J. Gen. Physiol.
    abstract

2009

  • Kline, CF, Kurata, H.T., Hund, T.J., Cunha, S.R., Koval, O.M., Wright, P.J. Christensen, M., Anderson, M.E., Nichols, C.G., and P.J. Mohler. 2009. Dual role of KATP channel C-terminal motif in membrane targeting and metabolic regulation. PNAS. abstract
  • Remedi, M.S., Kurata, H.T., Scott, A., Wunderlich, F.T., Rother, E., Kleinridders, A., Tong, A., Bruening, J.C., Koster, J.C., and C.G. Nichols. 2009. Consequences of β-cell inexcitability: Identification and prevention in a murine model of KATP-induced Neonatal Diabetes Mellitus. Cell Metabolism. abstract

2008

  • Flagg, T.P., Kurata, H.T., Magnuson, M., Coetzee, W.A., Lefer, D.J., and C.G. Nichols. 2008. Differential makeup of atrial and ventricular KATP: Atrial KATP channels are encoded by SUR1. Circ. Res. abstract
  • Kurata, H.T., Diraviyam, K., Marton, L.J., and C.G. Nichols. 2008. Blocker protection by short polyamine analogs: refined mapping of the spermine binding site in a Kir pore. Biophys. J. abstract
  • Koster, J.C., Kurata, H.T., Enkvetchakul, D., and C.G. Nichols. 2008. A DEND mutation in Kir6.2(KCNJ11) identifies an interfacial gating hinge of the KATP channel. Biophys. J. abstract
  • Kucheryavykh, Y.V., Shuba, Y.M., Antonov, S.M., Inyushin, M.Y., Cubano, L., Pearson, W.L., Kurata, H.T., Reichenbach, A., Veh, R.W., Nichols, C.G., Eaton, M.J., and S.N. Skatchkov. 2008. Complex recfication of Muller cell Kir currents. Glia. abstract

2007

  • Rezazadeh S.R., Kurata, H.T., Claydon, T.W., Kehl, S.J., and D. Fedida. 2007. An activation gating switch in Kv1.2 is localized to a threonine residue in the S2-S3 linker. Biophys. J. abstract
  • Kurata, H.T., Cheng, W., Arrabit, C., Slesinger, P.A., and C.G. Nichols. 2007. The role of the cytoplasmic pore in inward rectification of Kir2.1 channels. J. Gen. Physiol. abstract
  • Kucheryavykh, Y.V., Pearson, W.L., Kurata, H.T., Eaton, M.J., Skatchkov, S.N., and C.G. Nichols. 2007. Unique features of Kir4.1 channel rectification. Channels. abstract

2006

  • Kurata., H.T., Marton, L.J., and C.G. Nichols. 2006. The polyamine binding site in inward rectifier K+ channels. J. Gen. Physiol. abstract
  • Kurata, H.T., Fedida, D. 2006. A Structural Interpretation of Kv Channel Inactivation. Prog. Mol. Biol. Biophys. abstract

…2005

  • Kurata, H.T. Doerksen, K.W., Eldstrom, J.R., Rezazadeh, S., Fedida, D. 2005. Distinction of U-type and P/C-type inactivation pathways in truncated forms of Kv1.5. J. Physiol. abstract
  • Kurata, H.T., Phillips, L.R., Rose, T., Loussouarn, G., Herlitze, S., Fritzenschaft, H., Enkvetchakul, D., Nichols, C.G., and T. Baukrowitz. 2004. Molecular Basis of Inward-rectification: Polyamine interaction sites located by combined channel and ligand mutagenesis. J. Gen. Physiol. abstract
  • Kurata, H.T., Wang, Z., and D. Fedida. 2004. Inactivation peptide binding to C-type inactivated K+ channels. J. Gen. Physiol. abstract
  • Zhang, S., Kurata, H.T., Kehl, S.J., and D. Fedida. 2003. Rapid induction of P/C-type inactivation is the mechanism for acid-induced K+ current inhibition. J. Gen. Physiol. abstract
  • Kurata, H.T., Soon, G.S., Eldstrom, J.R., Lu, G.W.K., Steele, D.F., and D. Fedida. 2002. Amino-terminal determinants of U-type inactivation in voltage-gated K+ channels. J. Biol. Chem. abstract
  • Kurata, H.T., Soon, G.S., and D. Fedida. 2001. Altered state dependence of C-type inactivation in the long and short forms of human Kv1.5. J. Gen. Physiol. abstract